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Abstract
This study aimed at evaluating possible association between MDM2 SNP309 polymorphism (rs 2279744) and polycystic ovary syndrome (PCOS). One hundred and twenty-five women with PCOS and two hundred and fifty women without PCOS were collected from the department of reproductive medicine of college hospital in this case–control study. Peripheral blood samples were collected from all participants and DNA was extracted, MDM2 SNP309 polymorphism (rs 2279744) was determined from the 125 cases and 250 controls. Women were grouped into PCOS (n = 125) group and control group (n = 250). Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the association between MDM2 SNP309 polymorphism (rs 2279744) and PCOS. The distribution of T allele was significant higher in PCOS cases than controls. MDM2 SNP 309 T allele is associated with PCOS.
Chinese abstract
该研究目的为评估MDM2启动子SNP309多态性与PCOS风险的关系；研究方法：选125名PCOS患者与250名健康妇女为研究对象。取所有入组人员的外周血进行DNA检测。计算MDM2启动子SNP309多态性(rs2279744)与PCOS的OR值及95%置信区间。结果：与对照组相比，PCOS组T等位基因分布更多。结论：MDM2启动子SNP309 T等位基因与PCOS相关。
Acknowledgements
The authors thank the total participants and staff for continuing contributions.
Declaration of interest
No conflicts of interest were reported by all authors in this study. This work was financially supported by the Fund of State Key Laboratory of Genetics Resources and Evolution (No. GREKF10-07).