Management of polycystic ovarian syndrome with Diane-35 or Diane-35 plus metformin

Abstract

In this study, we assessed the efficacy and safe usage of the oral contraceptive, Diane-35, in the treatment of polycystic ovary syndrome (PCOS) when combined with the drug metformin. Eighty-two patients with PCOS were randomly divided into two equal groups: Diane-35 treatment group and Diane-35 plus metformin group. Three treatment cycles were administered. Patients’ biomedical data such as height, weight, waist circumference, hip circumference, body fat percentage, acne score, hirsutism score and serum hormone levels were selected, which were tested between the second and the fifth day of the menstrual cycle and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), blood glucose, blood lipids and insulin levels(IR) were analyzed. Significant reduction in body mass index (BMI), acne score, LH and T levels were observed in both groups after three months of treatment; on the other hand, high-density lipoprotein cholesterol (HDL) concentration elevated (p < 0.05). Combined treatment group had a significant change in BMI index and fasting blood glucose levels compared to Diane-35 alone treatment group (p < 0.05). With personalized nutrition and exercise program, Diane-35 only group or Diane-35 plus metformin group had both significantly lowered their serum testosterone levels and had improved acne symptoms. Diane-35 plus metformin combination had shown reduced fat percentage levels in patients with PCOS, and had shown improved glucose and lipid metabolism.

Chinese abstract

在这项研究中，我们评估了口服避孕药，达英-35联合二甲双胍在治疗多囊卵巢综合征中的有效性和安全性，82名多囊卵巢综合征的患者被随机分为两组：达英-35治疗组和达英-35联合二甲双胍治疗组。进行三个治疗周期。患者的生物医学数据，如身高、体重、腰围、臀围、身体脂肪百分比、痤疮评分、多毛评分和血清性激素水平被选定，并于月经周期的第2至第5天测定。并且检测患者的卵泡刺激素、促黄体生成素、睾酮、血糖、血脂和胰岛素水平。经过三个月的治疗，发现身体质量指数、痤疮评分、促黄体生成素和睾酮都有明显的降低。另一方面，高密度脂蛋白浓度升高了（p50.05）。与单独使用达英-35的治疗组相比，联合治疗组的身体质量指数和空腹血糖水平都有明显的改变（p50.05）。采取个体化的营养和锻炼计划，无论是单独达英-35治疗组或者达英-35联合二甲双胍治疗组，血清睾酮水平均有明显的降低，痤疮症状得到了改善。多囊卵巢综合征的达英-35联合二甲双胍治疗组的患者身体脂肪百分比水平降低了，血糖和血脂得到了改善。

• Body mass index
• diane 35
• hirsutism
• metformin
• polycystic ovary syndrome

Acknowledgements

We give thanks to all the participated patients and their family, and all clinic coordinators in this study.

Declaration of interest

The authors declare no conflicts of interest.