The impact of unilateral salpingectomy on antral follicle count and ovarian response in ICSI cycles: comparison of contralateral side

Abstract

Objective: To determine the impact of salpingectomy on the ovarian reserve. Comparisons are made with the contralateral side in patients with unilateral salpingectomy undergoing intracytoplasmic sperm injection (ICSI) cycles.

Study design: Patients under 40 with unilateral salpingectomy and without history of ovarian surgery were selected for the multicentre retrospective study. Women with bilateral salpingectomy and history of endometriosis were excluded from the study. Antral follicle count, controlled ovarian hyperstimulation (COH) parameters and number of collected oocytes were the main outcome measures of the study.

Results: A total of 56 patients were eligible for this study. The mean age of the patients was 31.6 ± 4.7 years. The reasons for the salpingectomy were hydrosalpinx (39.3%, n = 22) and ruptured ectopic pregnancy (60.7%, n = 34). The ongoing pregnancy rate per embryo transfer was 30.6%. There was no statistically significant difference between the operated and non-operated sides in antral follicle count (AFC), follicles  ≥ 17 mm and 10–17 mm on day of human chorionic gonadotrophin (hCG), or number of aspirated oocytes. In the subgroup analysis, AFC, number of growing follicles on day of hCG and number of collected oocytes were comparable between the ectopic pregnancy group and hydrosalpinx group.

Conclusion: The study suggests that salpingectomy is not associated with detrimental effects on AFC and ovarian response.

Chinese abstract

目的：为了确定输卵管切除术对卵巢储备的影响, 将进行ICSI周期单侧输卵管切除术的患者与对侧进行比较。

研究设计：选择单侧输卵管切除术和无卵巢手术史的40岁以下的患者进行多中心回顾性研究, 具有双侧输卵管切除术史和子宫内膜异位史的妇女被排除在研究之外。窦卵泡计数, 控制性卵巢超刺激 (COH) 参数和收集的卵母细胞数量是研究的主要测量结果。

结果：共有56名患者符合本研究的条件, 患者的平均年龄为31.6 ± 4.7岁。输卵管切除术的原因是血管栓塞 (39.3%, n = 22) 和异位妊娠破裂 (60.7%, n = 34) , 每胚胎移植的持续怀孕率为30.6%。手术和非手术侧在窦卵泡计数 (AFC) , 人绒毛膜促性腺激素 (hCG) 当天17mm的卵泡和10-17mm的卵泡或吸出的卵母细胞数方面没有显著的统计学差异。在亚组分析中, 在 hCG日, AFC, 生长卵泡数和收集的卵母细胞数在异位妊娠组和输卵管积水组之间是相当的。

结论：研究表明输卵管切除术与对AFC和卵巢反应的不利影响不相关。

Keywords:

• Antral follicle count
• controlled ovarian stimulation
• in vitro fertilization
• ovarian reserve
• salpingectomy

Declaration of interest

The authors declare no conflict of interests and no funding support.