Abstract
In a prospective study, we investigated the impact of anti-Müllerian hormone (AMH) changes following ovarian cyst surgery on the probability to achieve pregnancy and live birth. Women of reproductive age (n = 60) were included before surgery for benign ovarian cysts. Serum AMH concentrations were determined pre- and postoperative at 6 and 24 months. Information regarding pregnancy wish and attempts to conceive were obtained by a questionnaire. At the time of inclusion, 45/60 women reported desire of children. At six months, the levels of AMH decreased significantly in the whole group and further reduction was observed at two years (from 2.7 μg/L to 2.0 μg/L to 1.1 μg/L, respectively, p< 0.008), with a percentage reduction of 42.9%. At two-year follow-up, 36 women reported to have attempted to conceive and 18 achieved pregnancy (50%), with a live birth rate of 33%. The percentage change in AMH at two years did not differ significantly between the women who conceived versus those who did not (p = 0.117). Data reported herein demonstrate that the AMH reduction following ovarian cyst surgery is maintained two years after surgery; however, the postoperative AMH decrease that follows ovarian cyst surgery might not reduce the chances to achieve pregnancy.
Chinese abstract
在一项前瞻性研究中, 我们研究了卵巢囊肿手术后抗苗勒管激素(AMH) 的变化对术后受孕与活产的影响。研究纳入了良性卵巢囊肿手术前的育龄期女性(n = 60) , 测定术前及术后6个月、24个月的血清AMH浓度。受试者的妊娠意愿及尝试受孕的相关信息通过问卷调查获得。入组时, 60名女性中有45名表示有妊娠意愿。术后6个月, 全组女性的AMH水平明显下降, 术后2年进一步下降(由2.7μg/L降至2.0μg/L, 再到1.1μg/L) , 下降百分率为42.9%。在2年的随访中, 36例女性尝试受孕, 18例女性妊娠(50%) , 活产率为33%。受孕女性与未受孕女性相比, 两者间术后2年的AMH变化没有明显差异 (p = 0.117) 。本研究结果显示, 卵巢囊肿术后2年AMH水平持续降低, 但可能并不会导致妊娠率减少。
Declaration of interest
The authors report no conflicts of interest.