The Transition from Pubertal Development to Postmenopause Discloses a Gonadotropin-Releasing Hormone-Independent Mechanism Regulating Follicle-Stimulating Hormone Release

Abstract

The reproductive function is tightly dependent on gonadotropin secretion and the optimal activity of the hypothalamus—pituitary axis. This study discusses evidence that supports the possible existence of a GnRH-independent modulator of FSH secretion in humans. Such a hypothesis has been consistently reported in several experimental animals. To test the hypothesis specific times during the physiological development and activity of the hypothalamus-pituitary axis have been evaluated under the use of drugs acting directly on hypothalamic GnRH-secreting neurons, such as GnRH agonists. The possible presence also in humans of such an independent FSH stimulator might be important for the understanding of anovulation and infertility.

Key Words:

• Gnrh
• Puberty
• Menstrual Cycle
• Menopause
• Gonadotropin
• Gnrh Agonist And Antagonist