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Original Article

Mean platelet volume as an inflammatory marker in patients with severe periodontitis

, , , , &
Pages 67-71 | Received 02 Aug 2013, Accepted 07 Dec 2013, Published online: 05 Feb 2014
 

Abstract

Periodontitis has become the leading cause of tooth loss in adults, and the host’s immunologic and inflammatory response to the bacteria can lead to periodontal destruction. In patients with periodontitis, platelets possess an increased activation status compared with platelets from healthy controls. Mean platelet volume (MPV) has been considered an important index of platelet activity and an inflammatory marker in many infectious diseases. The present study investigated the relationship between MPV and disease activity in subjects with severe periodontitis. Forty-five patients with periodontitis and 45 age and sex-matched healthy subjects were enrolled into the study. All subjects received periodontal and hematological examinations. The periodontitis patients were administered active periodontal treatment (APT). At baseline, a statistically significant decrease in MPV was noted in patients with periodontitis (9.73 ± 1.06 fL) compared with healthy controls (10.24 ± 1.07 fL). At 1 month post-APT, MPV was substantially increased (10.11 ± 1.04 fL). Positive correlation was found between increase of MPV and decrease of periodontal probing depth after treatment(r = 0.377; p = 0.014). In conclusion, the decrease of MPV was related to the severe periodontal inflammation, and the value inversed shift after APT. MPV might reflect the disease activity of periodontitis.

Declaration of interest

This study was supported by the National Natural Science Foundations of China Beijing, China (30471882, 30973319, 81271149, 81300879); National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China (2002AA217091, 2007BAI18B02); Key program of Clinical Specialty, National Ministry of Health P.R.C., Beijing, China; Capital Medical Development Research Foundation of Beijing, China (2009–2033). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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