Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation

Abstract

Cardiovascular disease prevention is of high priority in developed countries. Healthy eating habits including the regular intake of an antithrombotic diet (fruit and vegetables) may contribute to prevention. Platelet function is a critical factor in arterial thrombosis and the effect strawberries have is still unclear. Therefore, the aim of this study was to systematically examine the action of strawberries in preventing platelet activation and thrombus formation. Strawberry extract concentration-dependently (0.1–1 mg/ml) inhibited platelet aggregation induced by ADP and arachidonic acid. At the same concentrations as strawberry inhibits platelet aggregation, it significantly decreased sP-selectin, sCD40L, RANTES, and IL-1β levels. The strawberry may exert significant protective effects on thromboembolic-related disorders by inhibiting platelet aggregation. Also, this suggests that antithrombotic activity may have novel anti-inflammatory effects.

• Antiplatelet
• antithrombotic
• IL-1β
• P-selectin
• RANTES
• sCD40L
• strawberry

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. This work was funded by the CONICYT REGIONAL/GORE MAULE/CEAP/R09I2001, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), and supported by grant no. 1130216 (I. P., M. G., R. M., M. A., and J. C.) from Fondecyt, Chile.