An unusual presentation of scabies infestation in a patient with Darier's disease. The use of ivermectin as an adjunctive scabicide

Abstract

Darier's disease is an inherited condition of defective keratinization in which patients are predisposed to the development of severe viral infections and have an increased susceptibility to bacterial and mycotic infections. We describe a patient with Darier's disease who had a severe form of scabies infestation which responded to treatment with permethrin in combination with ivermectin. The tendency of patients with Darier's disease to develop severe forms of cutaneous infections and infestations may reflect a common underlying mechanism, and their management may require more aggressive therapeutic approaches.

Key Words:

• Darier's disease
• Scabies
• Permethrin
• Ivermectin