Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress

Abstract

Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Gingerols, the major pungent components of ginger, are known to improve diabetes, including the effect of enhancement against insulin sensitivity. In the current study, ginger sequentially extracted with different solvents—namely, hexane, ethyl acetate, methanol, 70% methanol–water and water—were screened to determine the variations in phenolic-linked active constituents. The potential of these extracts to inhibit key enzymes relevant to type 2 diabetes and inflammation was studied. Phenolic compounds—namely, gingerols and shoagols—were quantified using high-performance liquid chromatography. Ethyl acetate extract showed higher activity compared with other extracts. These studies indicate that ginger has very good potential for α-glucosidase and α-amylase inhibition relevant for type 2 diabetes management and cyclooxygenase inhibition for inflammation.

Keywords::

• α-Glucosidase
• α-amylase
• cyclooxygenase
• reactive oxygen species
• flow cytometer
• C2C12

Acknowledgements

The authors are thankful to the Director, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR for providing all the facilities for carrying out this work.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.