Regular consumption of Fiit-ns, a polyphenol extract from fruit and vegetables frequently consumed within the Mediterranean diet, improves metabolic ageing of obese volunteers: a randomized, double-blind, parallel trial

Abstract

Epidemiological studies suggest that metabolic ageing process of overweight and obese populations is associated with an increased risk of developing non-communicable diseases (NCDs). Inflammation, hyper-glycaemia, dyslipidemia and oxidative stress have been associated with early stages of NCDs development whereas cohort surveys have demonstrated health benefits of dietary polyphenols from various dietary sources to reverse such progress. Obese volunteers were included in a double-blind, randomized, parallel pilot trial where they received daily for a 12-week period 900 mg of a polyphenol-rich treatment extracted from fruit and vegetables frequently consumed within the Mediterranean diet. Anthropometric and blood parameters were assessed before and at the end of the intervention period. After 12 weeks, while the silhouette slimmed down, metabolic parameters were significantly improved and general satisfaction considerably ameliorated. These data suggest that over a 12-week period, the synergistic action of bioactives within the treatment improves metabolic ageing process and quality of life in obese volunteers.

• Chronic low grade inflammation
• dyslipidemia
• insulin resistance
• Mediterranean diet
• oxidative stress
• quality of life

Acknowledgements

The financial assistance of Fytexia is gratefully acknowledged.

Declaration of interest

Fytexia is involved in the research & development and marketing & sales of polyphenol extracts from various fruit and vegetables regularly consumed within the Mediterranean diet for food and nutraceutical industries. Therefore, Fytexia has a commercial interest in this publication. RDVC and “Association Nationale de Prévention Médicale” were paid by Fytexia to perform and report the scientific work that formed the basis of this publication. Fytexia, RDVC and “Association Nationale de Prévention Médicale” declare that the data in this report represent a true and faithful representation of the work that has been performed.