Wheat aleurone fractions and plasma n−3 fatty acids in rats

Fayçal OunnasLaboratoire TIMC-IMAG CNRS UMR 5525, Equipe PRETA, Cœur et Nutrition, Université Joseph Fourier, Grenoble I, France, ;Laboratory of Fundamental and Applied Bioenergetics (LBFA), Université Grenoble Alpes, Grenoble, France, ;Inserm, U1055, Grenoble, France, Correspondence[email protected]

Patricia SalenLaboratoire TIMC-IMAG CNRS UMR 5525, Equipe PRETA, Cœur et Nutrition, Université Joseph Fourier, Grenoble I, France,

Christine DemeilliersLaboratory of Fundamental and Applied Bioenergetics (LBFA), Université Grenoble Alpes, Grenoble, France, ;Inserm, U1055, Grenoble, France,

Luca CalaniLS9 Interlab Group, The Laboratory of Phytochemicals in Physiology, Department of Food Science, University of Parma, Parma, Italy, ;Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy,

Francesca ScazzinaLS9 Interlab Group, The Laboratory of Phytochemicals in Physiology, Department of Food Science, University of Parma, Parma, Italy, ;Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy,

Florence Hazane-PuchDépartement de Biochimie, Pharmacologie et Toxicologie, Unité Biochimie Hormonale et Nutritionnelle, Secteur Lipides, Centre Hospitalier et Universitaire de Grenoble, Grenoble, France, and

Francois LaporteDépartement de Biochimie, Pharmacologie et Toxicologie, Unité Biochimie Hormonale et Nutritionnelle, Secteur Lipides, Centre Hospitalier et Universitaire de Grenoble, Grenoble, France, and

Camilla MelegariBarilla G. R. Fratelli Spa. 166, Parma, Italy

Daniele Del RioLS9 Interlab Group, The Laboratory of Phytochemicals in Physiology, Department of Food Science, University of Parma, Parma, Italy, ;Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy,

Michel de LorgerilLaboratoire TIMC-IMAG CNRS UMR 5525, Equipe PRETA, Cœur et Nutrition, Université Joseph Fourier, Grenoble I, France,

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Abstract

The main aim of this study was to compare the effects of two wheat aleurone (WA) fractions on circulating n−3 fatty acids in rats. We demonstrated that only the fraction able to induce the highest urinary excretion of polyphenol metabolites (>1µmol) resulted in a significant increase in plasma level of Eicosapentanoic acid (+22%, p < 0.05). While other constituents of whole wheat can be involved in this response, our data suggest that cereals containing high levels of phenolic compounds can increase blood n−3 without affecting n−6 fatty acids. Further studies are required to confirm this hypothesis and explore the underlying biological mechanisms.

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Declaration of interest

Ounnas, Demeilliers, Calani, Hazane-Puch and Laporte have no conflicts of interest. Salen and de Lorgeril (through Grenoble University School of Medicine), Del Rio and Scazzina (through Parma University) disclose receiving research grants from the Barilla G&R F.lli Company. Melegari is an employee of Barilla G. R. Fratelli Spa.

This project has been funded by Barilla G. R. Fratelli Spa and supported in part by the 7th ATHENA Framework Program [Grant agreement No.: 245121] from the European Community.

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Wheat aleurone fractions and plasma n−3 fatty acids in rats

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Wheat aleurone fractions and plasma n−3 fatty acids in rats

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