Chromatographic, toxicological and metabolic studies on the volatile extract of aspartic acid-fructose in rats

Abstract

The effect of browned volatile aroma concentrate of aspartic acid (A)-fructose (F) interaction at 120d`C on the growth rate and metabolism of Swiss albino adult female rats was studied. Rats received either low or high doses of A-F 120 (0.1 and 0.25 LD 50) intragastrically for 12 weeks, exhibited a lag in the weight gain due to diarrhoea, as well as a significant increase in organ/whole body weight ratio regarding liver, kidney, stomach and caecum compared to normal controls. This mode of dietary treatment resulted in a significant reduction in the levels of serum cholesterol, triglycerides, total protein, albumin and liver total lipid, while a significant elevation in the levels of serum glucose, urea nitrogen and liver glycogen, as well as some enzyme activity in the serum and liver tissue of both groups of animals are reported and discussed, accordingly.