Effects of chronic social stress during lactation on maternal behavior and growth in rats

Abstract

Maternal mood disorders such as depression and chronic anxiety can negatively affect the lives of not only mothers, but also of partners, offspring, and future generations. Chronic exposure to psychosocial stress is common in postpartum mothers, and one of the strongest predictors of postpartum depression is social conflict. The objective of the current study was to evaluate the effects of chronic social stress (CSS) during lactation on the maternal behavior (which consists of maternal care and aggression toward a novel conspecific) of lactating rats, as well as on the growth of the dams and their offspring. It was hypothesized that chronic daily exposure to a novel male intruder would alter the display of maternal behavior and impair growth in both the dam and offspring during lactation due to the potentially disruptive effects on maternal behavior and/or lactation. The data indicate that CSS during lactation attenuates maternal care and the growth of both dams and pups, and increases self-grooming and maternal aggression toward a novel male intruder. These results support the use of CSS as a relevant model for disorders that impair maternal behavior and attenuate growth of the offspring, such as postpartum depression and anxiety.

Keywords::

• Anxiety
• depression
• maternal aggression
• maternal care
• offspring development
• social behavior

Acknowledgements

The authors would like to thank Dr Klaus Miczek, Dr Sherryl Goodman and Dr Paula Brunton for their input on the design of the CSS protocol.

Declaration of Interest. The authors have no conflict of interest, and are responsible for the content and writing of this paper.