New Developments in Therapeutic Chelating Agents as Antidotes for Metal Poisoning

Abstract

An examination of the studies on therapeutic chelating agents that have been carried out during the last decade reveals that extensive efforts have been made to develop compounds superior to those previously available for the treatment of acute and chronic intoxication by many metals. These metals include primarily iron, plutonium, cadmium, lead, and arsenic, but also many other elements for which acute and chronic intoxication is less common. These studies have revealed the importance of several additional factors of importance in the design of such compounds and have led to many new compounds of considerable clinical promise. An additional development has been the introduction of previously developed chelating agents for use with certain metals on a broader scale.

Key Words:

• antidotes for toxic metals
• cadmium intoxication
• chelating agents
• iron overload
• lead intoxication
• metal antidotes
• metal chelators
• plutonium mobilization
• toxic metal excretion
• stability constants
• Wilson's disease