Vanadium Salts as Insulin Substitutes: Mechanisms of Action, a Scientific and Therapeutic Tool in Diabetes Mellitus Research

Abstract

Vanadium and its compounds exhibit a wide variety of insulin-like effects. In this review, these effects are discussed with respect to the treatment of type I and type II diabetes in animal models, in vitro actions, antineoplastic role, treatment of IDDM and NIDDM patients, toxicity, and the possible mechanism(s) involved. Newly established CytPTK plays a major role in the bioresponses of vanadium. It has a molecular weight of approximately 53 kDa and is active in the presence of Co²⁺ rather than Mn²⁺. Among the protein-tyrosine kinase blockers, staurosporine is found to be a potent inhibitor of Cyt PTK but a poor inhibitor of InsRTK. Vanadium inhibits PTPase activity, and this in turn enhances the activity of protein tyrosine kinases. Our data show that inhibition of PTPase and protein tyrosine kinase activation has a major role in the therapeutic efficacy of vanadium in treating diabetes mellitus.

Key Words:

• vanadium
• peroxovanadium
• cytosolic protein tyrosine kinase
• insulin-receptor tyrosine kinase
• protein phosphotyrosine phosphatases
• insulin
• diabetes mellitus