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Abstract
Computer analyses of the 3′-flanking DNA sequence of the human elastase I gene revealed a significant degree of similarity with seven human gene sequences in the CenBank and EMBL databases. Cenomic Southern analysis indicates that the shared nucleotide sequences are a primate-specific family of short interspersed elements. These elements are members of MERI sequences (medium reiteration frequency sequences). The consensus sequence of MERI repeats spans 543 nucleot-ides and contains several inverted repeats. Since the copy number of MERI elements seems to be much smaller than that of Alu and L1 repeats, MERI elements may provide useful landmarks for human genome mapping.