Immunoglobulin Related Amyloidosis Presenting as Isolated Lymph Node and Pulmonary Involvement

G. Meeus Departments of Internal Medicine, Gasthuisberg University Hospital, Herestraat, 49 3000, Leuven, Belgium

J. Ponette Departments of Internal Medicine, Gasthuisberg University Hospital, Herestraat, 49 3000, Leuven, Belgium

J. Delabie Departments of Anatomopathology, Gasthuisberg University Hospital, Herestraat, 49 3000, Leuven, Belgium

J. Verschakelen Radiology, Gasthuisberg University Hospital, Herestraat, 49 3000, Leuven, Belgium

D. Blockmans Departments of Internal Medicine, Gasthuisberg University Hospital, Herestraat, 49 3000, Leuven, Belgium

Abstract

Here we present an unusual case of a 53-year old patient presenting AL-κ amyloidosis with diffuse-type amyloidosis of lungs, lymph nodes and pleura. The underlying pathology was a B-cell immunoglobulin-secreting non-Hodgkin lymphoma, as proven by the presence of a monoclonal B-cell population in the bone marrow. Diffuse parenchymal infiltration of the lungs is extremely rare in non-systemic amyloidosis, with only 4 previous cases having been reported in the English literature.

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Immunoglobulin Related Amyloidosis Presenting as Isolated Lymph Node and Pulmonary Involvement

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Immunoglobulin Related Amyloidosis Presenting as Isolated Lymph Node and Pulmonary Involvement

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