2′-Deoxycoformycin for Hepatosplenic γδ T-Cell Lymphoma

Abstract

We describe a patient with unusually indolent hepatosplenic γδ T cell lymphoma characterised by severe lassitude and high fever. No significant responses were obtained to a range of chemotherapeutic and biological agents. 2′-deoxycoformycin (dCF), however, produced a dramatic and sustained clinical and histological response. This is the second recent report of γδ T cell lymphoma responding to dCF, suggesting this agent may have a specific role in this condition.

Key Words:

• 2′- deoxycoformycin
• hepatosplenic
• T-cell lymphoma