Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia

Barbara Faganel KotnikDepartment of Oncology and Hematology, University Children's Hospital, University Medical Center Ljubljana, Ljubljana, Slovenia

Vita DolžanInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Iztok GrabnarDepartment of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

Janez JazbecDepartment of Oncology and Hematology, University Children's Hospital, University Medical Center Ljubljana, Ljubljana, SloveniaCorrespondence[email protected]

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Declaration of interest: The study was financially supported by the Slovenian Research Agency (ARRS Grants P3-0343, L3-0624, and PO-0503-0381).

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Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia

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Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia

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