Polo-like kinase 1 is essential to DNA damage recovery

Abstract

Radiation treatment and chemotherapy can both cause DNA damage to tumor cells. Tumor cells have specific self-protecting mechanisms to escape death. In this study, we explored the effects of polo-like kinase 1 on the DNA damage recovery system in lymphoma cell lines. DNA damage caused inhibition of polo-like kinase 1 activity and induced cell cycle arrest at the G2/M phase. Once the DNA damage was repaired, polo-like kinase 1 activity was restored and cell cycle arrest was removed. Unexpectedly, polo-like kinase 1 depletion hampered the cell cycle progress of cells recovered from DNA damage, and induced apoptosis.

Keywords:

• Polo-like kinase 1
• DNA damage
• cell cycle
• apoptosis

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.