The Hammersmith Hospital hematopathology case of the month: Myeloid sarcoma with Langerhans cell proliferation

Abstract

We present a patient whose initial lymph node biopsy showed extensive histiocyte and Langerhans cell infiltration, which obscured the underlying myeloid sarcoma (MS). The initial diagnosis of Langerhans cell histiocytosis (LCH) was not compatible with the disease evolution, and a subsequent biopsy performed much later showed all the characteristics of MS. Clinical distinction between LCH and MS involving the skin and management of these diseases, and the reported association of LCH/Langerhans cell proliferations with myeloid and lymphoid malignancies, are discussed.

Keywords:

• Myeloid sarcoma
• acute myeloid leukemia
• granulocytic sarcoma
• Langerhans cell
• Langerhans cell histiocytosis
• histiocytosis

View correction statement:

Corrigendum

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.