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Abstract
SOX11 is a transcription factor involved in embryonic neurogenesis and tissue remodeling. Its role in lymphopoiesis is still unknown. Recent studies have shown the specific overexpression of SOX11 mRNA and nuclear protein in both cyclin D1-positive and -negative mantle cell lymphoma (MCL). In addition to MCL, SOX11 is strongly expressed in hairy cell leukemia, Burkitt lymphoma, and immature lymphocytic neoplasms. Expression of SOX11 in MCL is not only a new diagnostic marker, but may also carry information related to the clinical and biological behavior. Further study of the biology may reveal common pathways to neoplasia related to SOX11 expression.
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Declaration of interest: This study was supported by the National Natural Science Foundation of China (30871104, 30971295, 30971296), Jiangsu Province's Outstanding Medical Academic Leader Program (LJ200623), Jiangsu Province's Medical Elite Program (RC2007042), the ‘Qing Lan’ project of Jiangsu Province, and ‘Liu Da Ren Cai Gao Feng’ of Jiangsu Province.