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Original Articles: Clinical

Prognostic impact of MUM1 expression by immunohistochemistry on primary mediastinal large B-cell lymphoma

, , , &
Pages 1495-1503 | Received 14 Jan 2011, Accepted 14 Jan 2011, Published online: 31 May 2011
 

Abstract

Diffuse large B-cell lymphoma can be classified into two prognostically distinct subgroups with germinal center B-cell-like (CG) and activated B-cell-like (post-CG) characteristics, based on CD10, BCL-6, and MUM1 expression. We performed a retrospective analysis of the clinical variables of 37 patients with primary mediastinal large B-cell lymphoma and the expression of BCL-6 and MUM1 in 22 patients with available tissue. The median age was 30 years, and 70% of the patients were female. BCL-6 and MUM1 were expressed in 64% and 45% of cases, respectively. Five-year overall survival (OS) and disease-free survival (DFS) were 47% and 81%, respectively. In univariate analysis, complete response (p = 0.0001), radiation therapy (p = 0.01), International Prognostic Index (p = 0.001), and MUM1 expression (p = 0.002) correlated with OS. For this group of patients with homogeneous clinical characteristics, response to initial chemotherapy and MUM1 expression were associated with prognosis.

Acknowledgements

We thank Cesar Nascimento Braga for his skilled technical assistance with staining reactions. We thank Dr. Ines Nishimoto for assistance with the statistics.

Potential conflict of interest: Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

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