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Abstract
The purpose was to describe the incidence and risk factors associated with early deaths (≤ 42 days from diagnosis) among children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in Ontario, Canada. The data source for this population-based, retrospective cohort study was the Pediatric Oncology Group of Ontario Networked Information System (POGONIS). Patients with acute leukemia aged ≤ 18 years diagnosed between 1990 and 2010 were included. The study population consisted of 1954 children with ALL and 403 with AML. The early death rate was 40/2357 (1.7%), with 1.1% of patients with ALL and 4.7% of patients with AML dying early. Among all 442 deaths recorded, 9.0% occurred early. Twelve/40 (30.0%) early deaths were attributed to infection. Factors associated with early deaths were AML (p < 0.0001) and age ≥ 10 years at diagnosis (p = 0.038). Future interventions to improve survival may consider focusing on the early treatment period and may target AML and older patients.
Acknowledgements
The authors would like to thank the TSUF from The Hospital for Sick Children Research Institute for supporting the project. L.S. is supported by a New Investigator Award from the Canadian Institutes of Health Research.
Potential conflict of interest:
Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.