Jagged-1: a new promising factor associated with favorable prognosis in patients with acute myeloid leukemia

Abstract

In this study Jagged-1 and Dll-1 surface expression as well as Notch-1 receptor intracellular domain (Notch-1-IC) expression were assessed by multi-color flow cytometry in leukemic blasts obtained from 88 patients with acute myeloid leukemia (AML). CD34 + peripheral blood stem cells (PBSCs) were used as a control. The median expression of Jagged-1 and Dll-1 was significantly higher in AML blasts than in PBSCs (p = 0.001 and p = 0.002, respectively). Higher expression of Notch-1-IC was detected in patients with poor-risk karyotype as compared to good- and intermediate-risk groups (p = 0.035). In our study, poor-risk cytogenetics and low (< median) expression of Jagged-1 were the only factors associated with significantly shorter overall survival in intensively treated patients according to multivariate analysis. In conclusion, high Jagged-1 surface level in leukemic cells is an independent favorable prognostic factor in patients with AML. To our knowledge, this is the first study evaluating the prognostic role of Notch-1-IC in AML blasts.

Keywords::

• Myeloid leukemias and dysplasias
• prognostication
• signaling therapies

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

This work was supported by grants Nr 502-03/1-093-01/502-14-078 and 503/1093/1 from the Medical University of Lodz, Poland as well as the Foundation for the Development of Diagnostics and Therapy, Warsaw, Poland.