Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection

Abstract

Mantle cell lymphoma (MCL) is a rare B-cell malignancy that carries a relatively poor prognosis compared to other forms of non-Hodgkin lymphoma. Standardized preclinical tools are desperately required to hasten the discovery and translation of promising new treatments for MCL. Via an initiative organized through the Mantle Cell Lymphoma Consortium and the Lymphoma Research Foundation, we gathered MCL cell lines from laboratories around the world to create a characterized MCL Cell Bank at the American Type Culture Collection (ATCC). Initiated in 2006, this collection now contains eight cell lines, all of which have been rigorously characterized and are now stored and available for distribution to the general scientific community. We believe the awareness and use of these standardized cell lines will decrease variability between investigators, harmonize international research efforts, improve our understanding of the pathogenesis of the disease and hasten the development of novel treatment strategies.

Keywords::

• Mantle cell lymphoma
• non-Hodgkin lymphoma cell bank
• cell lines

Acknowledgements

The authors thank the LRF and its donors for their support of this work, as well as the originators of the mantle cell lines who have so generously provided them to the scientific community (Table I). We also thank the MCL Cell Bank Working Group (O. A. O’Connor, Chair): Drs. W. C. Chan (University of Nebraska), R. Ford (M. D. Anderson Cancer Center, Houston), E. Sotomayor (Moffatt Cancer Center, Tampa) and L. Staudt and A. Wiestner (National Cancer Institute, Bethesda).

Potential conflict of interest

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