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Abstract
Mantle cell lymphoma has features of both indolent and aggressive non-Hodgkin lymphomas. Repeated relapses leading to treatment failure in patients with mantle cell lymphoma might suggest the presence of cancer stem cells. A small cell population with CD45+/CD19 − was previously reported to represent cancer stem cells. We evaluated the clinical relevance of CD45+/CD19 − cells in bone marrow of patients with mantle cell lymphoma (n = 20). A CD45+/CD19 − cell population was observed in newly diagnosed mantle cell lymphoma, and its percentage correlated with tumor cells in bone marrow (r = 0.832, p = 0.001) and score on the simplified mantle cell lymphoma prognostic index (r = 0.675, p = 0.016). After treatment, CD45+/CD19 − cells decreased (mean: 0.012%), and CD45+/CD19 − cells (0.276%) were higher at relapse or progression than at diagnosis. In conclusion, a CD45+/CD19 − cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.
Acknowledgements
This study was supported by grants from the Samsung Biomedical Research Institute (SBRI C-B0-211-2) and the National Research Foundation of Korea's Basic Science Research Program, which is funded by the Ministry of Education, Science and Technology (2012R1A1A2008573).
Potential conflict of interest
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