¹⁸F-Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography in mucosa-associated lymphoid tissue lymphoma: variation in ¹⁸F-FDG avidity according to site involvement

Abstract

The purpose of this study was to determine the ¹⁸F-FDG avidity of MALT lymphoma and the additional utility of ¹⁸F-FDG PET/CT in MALT lymphoma staging. Pretreatment ¹⁸F-FDG PET/CT scans of 222 patients with 227 MALT lymphoma lesions were retrospectively analyzed. ¹⁸F-FDG avidity of lesions was noted in 28%. The proportion was lower for gastric MALT lymphomas than for non-gastric lesions (9% vs. 60%, p < 0.0001) and higher for mass-forming lesions than for superficial lesions (82% vs. 2%, p < 0.0001). ¹⁸F-FDG PET/CT showed the presence of additional lesions in 23 patients: four of six true-positive lesions had ¹⁸F-FDG avid primary lesions, and 15 of 17 false-positive lesions had ¹⁸F-FDG-non avid lesions. ¹⁸F-FDG avidity differed according to the location and gross morphologic characteristics of the MALT lymphoma. Most gastric MALT lymphomas were superficial and had low ¹⁸F-FDG avidity. For staging, ¹⁸F-FDG PET/CT can be helpful mainly for ¹⁸F-FDG avid primary MALT lymphomas.

Keywords::

• Avidity
• ¹⁸F-FDG
• lymphoma
• mucosa-associated lymphoid tissue (MALT)
• PET
• staging

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