Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia

Jill A. Moormeier Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA

Carol A. Westbrook Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA

Mark J. Ratain Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA

Harvey M. Golomb Joint Section of Hematology/Oncology, the University of Chicago and Michael Reese Medical Centers, 5841 So. Maryland Avenue, Box 420, Chicago, IL, 60637, USA

Abstract

A patient with hairy cell leukemia is described who, during the course of treatment of his disease with interferon αb, developed antibodies to the drug. Coincident with antibody development, clinical resistance to the effect of alfa interferon was noted Despite an increasing dose of interferon, no signs of disease response were noted and the patient required a change in therapy to deoxycoformycin. Although similar findings have been described in patients treated with interferon alfa-2a, this is the first report of clinical resistance associated with neutralizing antibody formation in a hairy cell leukemia patient treated with interferon alfa-2b.

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Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia

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Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia

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