Inhibitory Anti-Tumor Effects of Interleukin-4 on Philadelphia Chromosome-Positive Acute Lymphocytic Leukemia and Other Hematopoietic Malignancies

Abstract

IL-4 has been shown to possess a broader spectrum of biological activities. Recently, anti-tumor activities of IL-4 on malignant tumors including hematopoietic tumors has been revealed in vitro or in vivo. We investigated the effect of recombinant human (rhIL-4) on the in vitro growth of human leukemia cells and demonstrated the inhibitory anti-tumor activity of rhIL-4 on Ph¹-positive ALL cells in association with the decreased activity of cellular tyrosine kinase. This finding suggests that the clinical evaluation of rhIL-4 may offer promising therapeutic possibility for patients with Ph¹-positive ALL. In this paper, we presented the IL-4-dependent inhibition of Ph¹-positive ALL cells and reviewed implications for mechanism of IL-4-dependent inhibition and anti-tumor activities of IL-4.

Key Words:

• Ph¹+ALL
• interleukin-4
• tyrosine kinase
• anti-tumor activity
• bcr/abl gene