Granulocytic Sarcomas of Small Intestine and Brain are Associated with Acute Myelomonocytic Leukaemia with Abnormal Eosinophils and Inversion of Chromosome 16

Abstract

We report two cases of acute myelomonocytic leukaemia with abnormal eosinophils (M4Eo) in which the presenting feature was small bowel obstruction. We suggest there is a unique clinicopathological association between small intestine involvement with leukaemia and the M4Eo subtype. Central nervous system involvement by myeloblastoma occurred in one of the two cases which is a recognised feature of M4Eo and should necessitate prophylaxis with intrathecal therapy. Inversion of chromosome 16 which is a cytogenetic marker for M4Eo was demonstrable in one of the two cases.

Key Words:

• Granulocytic sarcoma
• myeloblastoma
• inversion
• chromosome 16 AML
• M4Eo