Bone Marrow Necrosis and Human Parvovirus Associated Infection Preceding an Phl + Acute Lymphoblastic Leukemia

Tony Petrella Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Francois Bailly Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Francine Mugneret Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Denis Caillot Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Pascal Chavanet Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Henri Guy Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Eric Solary Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Anne Waldner Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Elisabeth Devilliers Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Paule-Marie Carli Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

Robert Michiels Departments of Pathology and Cytogenetic, Faculty of Medicine of Dijon and Departments of Laboratory Hematology, Clinical Hematology and Infectious Diseases, Hopital du Bocage de Dijon, France

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Abstract

A case of bone marrow necrosis associated with a serologically documented recent Parvovirus B 19 infection which preceded the development of PH1+ acute lymphoblastic leukemia is reported. No conclusions can be drawn on the basis of a single case but the question of the role of human Parvovirus B19 in the pathogenesis of bone marrow necrosis is discussed. It is suggested that the virus may act as a co-factor for the induction of bone marrow necrosis, in some cases.

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Bone Marrow Necrosis and Human Parvovirus Associated Infection Preceding an Phl + Acute Lymphoblastic Leukemia

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Bone Marrow Necrosis and Human Parvovirus Associated Infection Preceding an Phl + Acute Lymphoblastic Leukemia

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