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Leukemia & Lymphoma Volume 8, 1992 - Issue 6
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Original Article

Urinary Bladder Cancer Following Cyclophosphamide Therapy for Hodgkin's Disease

A. B. Pathak Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
,
S. H. Advani Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
,
R. Gopal Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
,
K. S. Nadkarni Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
&
T. K. Saikia Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
Pages 503-504 | Received 30 May 1992, Published online: 01 Jul 2009
 
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Abstract

Urinary bladder cancers following prolonged cyclophosphamide therapy are being increasingly reported. We report a case of transitional cell carcinoma of the urinary bladder occurring 12 years after pulse intravenous therapy with cyclophosphamide for Hodgkin's disease. The mechanism of bladder carcinogenesis and the possible role of the uroprotector MESNA in preventing cyclophosphamide induced bladder cancer are discussed.

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