Risk of Adult T-cell Leukemia Developing Individuals with HTLV-I Infection

Shimeru Kamihira Blood Transfusion Service, 7-1 Sakamoto-machi, Nagasaki, Japan

Yasuaki Yamada Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, Japan

Shuiti Ikeda Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, Japan

Saburo Momita Sunao Atogami Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, Japan

Hisashi Sohda Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, Japan

Masao Tomonaga Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, Japan

Shinkan Tokudome Department of Community Health Science, Saga Medical School, Saga, Japan

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Abstract

We examined the risk of ATL developing among anti-HTLV-I antibody-positive residents of Goto Island, an ATL-endemic area in Japan. In the period from 1986 to 1990, a total of 1,221 residents aged 40 or over were followed. The crude incidence rates for ATL (with 95% confidence intervals) were 577 per 100,000 (53-2,052) for males and 205 per 100,000 (19-755) for females, rates three to five times higher than those given in previous reports. The different levels of risk in various districts imply that there are risk factor(s) for ATL peculiar to the endemic area.

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Risk of Adult T-cell Leukemia Developing Individuals with HTLV-I Infection

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Risk of Adult T-cell Leukemia Developing Individuals with HTLV-I Infection

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