CD2⁺CD19⁺ Biphenotypic Acute Lymphoblastic Leukaemia: A Report of Three Cases and a Review of the Literature

S. H. Lim Departments of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

S. O'connor Departments of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

D. Bloxham Departments of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

R. Lynn Departments of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

V. Broadbent Paediatrics, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

M. J. S. Dyer Departments of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

R. E. Marcus Departments of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom

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Abstract

Biphenotypic acute lymphoblastic leukaemia expressing a pan-T CD2 and a pan-B CD19 antigen is very rare. In this report, we describe three such cases, focusing specially on the variable clinical and laboratory findings. We have also reviewed the literature on this unique form of acute lymphoblastic leukaemia which appears to behave differently to biphenotypic leukaemia coexpressing both myeloid and lymphoid markers.

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CD2⁺CD19⁺ Biphenotypic Acute Lymphoblastic Leukaemia: A Report of Three Cases and a Review of the Literature

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CD2+CD19+ Biphenotypic Acute Lymphoblastic Leukaemia: A Report of Three Cases and a Review of the Literature

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CD2⁺CD19⁺ Biphenotypic Acute Lymphoblastic Leukaemia: A Report of Three Cases and a Review of the Literature