Karyotypic Evolution in a Patient with a Preleukemic State of Adult T-cell Leukemia (Pre-ATL) progressing to Overt ATL

Naoki Sadamori Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Kenji Nishino Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Yukiyoshi Moriuchi Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Takahiro Itoyama Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Hideo Nakamura Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Ippei Sasagawa Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Seiji Tokunaga Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Takako Kawachi Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Shuichi Ikeda Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

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Abstract

Karyotypic evolution in a 56-year-old male with a preleukemic state of adult T-cell leukemia (pre-ATL) that progressed to overt ATL is described. The patient was born in the Kagoshima district, an endemic ATL area in Japan. A clone with inv(14)(q11q32) which was not detected in a pre-ATL state appeared during the early phase of overt ATL. These findings suggest that inv(14)(q11q32) may have played an important role in leukemogenesis in the present case. Based on our cytogenetic data obtained from both the pre-ATL and overt ATL phases, a model of the leukemogenic process of ATL is proposed.

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Karyotypic Evolution in a Patient with a Preleukemic State of Adult T-cell Leukemia (Pre-ATL) progressing to Overt ATL

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Karyotypic Evolution in a Patient with a Preleukemic State of Adult T-cell Leukemia (Pre-ATL) progressing to Overt ATL

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