Partial Trisomy lq, an Uncommon Chromosomal Aberration in Erythroleukemia

Abstract

A 2 years 4 months old boy with erythroleukemia (FAB-M6) and Down's syndrome is described. Chromosome analysis of bone marrow leukemic blasts revealed apart from the trisomy 21 a partial trisomy of the long arm of chromosome 1: lq23 +lqter in all cells and trisomy 8 mosaicism. To the best of our knowledge this is the first time that a partial trisomy of chromosome 1 in association with erythroleukernia has been described. Previous reports of other hematologic malignancies with aberrations of chromosome 1 indicate that the breakpoint lq23 is nonrandom and that trisomies of chromosome 1 plays a crucial role in the course of development of hematologic malignancies. This could probably also be true for erythroleukemias.

Key Words:

• Erythroleukernia
• M6
• partial trisomy 1