Cytoplasmic GpIIb-IIIa and Cytokine Secretion by Blasts in a Case of Megakaryoblastic Transformation of Essential Thrombocythemia

C. Sellen International Institute of Genetics and Biophysics (IIGB), Naples, Italy

F. Alfinito Division of Hematology, University of Naples, 2nd Medical School, Naples, Italy

L. Del Vecchio Immunohematology Service, Cardarelli Hospital, Naples, Italy

L. Luciano Division of Hematology, University of Naples, 2nd Medical School, Naples, Italy

A. De Renzo Division of Hematology, University of Naples, 2nd Medical School, Naples, Italy

B. Rotoli International Institute of Genetics and Biophysics (IIGB), Naples, Italy

Abstract

A 49-year-old woman with a four year history of therapy resistant essential thrombocythemia, progressed to acute leukemia that also proved refractory to chemotherapy. Blast cell features including immunophenotype, cytogenetics and in vitro cell cultures, suggested megakaryoblastic leukemia. In serum-free culture, blasts released GM-CSF and IL-6 which sustained autocrine growth and promoted normal myeloid and megakaryocytic colony formation.

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Cytoplasmic GpIIb-IIIa and Cytokine Secretion by Blasts in a Case of Megakaryoblastic Transformation of Essential Thrombocythemia

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Cytoplasmic GpIIb-IIIa and Cytokine Secretion by Blasts in a Case of Megakaryoblastic Transformation of Essential Thrombocythemia

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