Determination of IL6, IL1, and IL4 in the Plasma of Patients with Multiple Myeloma

T. L. Kiss Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

J. H. Lipton Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

D. E. Bergsagel Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

J. M. Meharchand Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

N. Jamal Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

M. D. Minden Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

H. A. Messner Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Toronto, Canada

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Abstract

Interleukin 6 (IL6) plasma levels were measured in 63 patients with multiple myeloma and 8 individuals with benign monoclonal gammopathy. 15 of these 71 samples showed by an enzyme linked immunosorbent assay (ELISA) detectable levels that ranged from 5 to 107 pg of IL6/ml. The IL6 levels of patients with multiple myeloma did not differ significantly from those of normal individuals (N = 25, range 5-27 pg IL6/m1) (Student's t-test, p = 0.295). The samples were negative for IL4; 3 were found positive for IL1β. A correlation between IL6, IL4 and IL1β levels and disease status was not observed for this group of patients.

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Determination of IL6, IL1, and IL4 in the Plasma of Patients with Multiple Myeloma

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Determination of IL6, IL1, and IL4 in the Plasma of Patients with Multiple Myeloma

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