Autoreactive T Cell-Dependent Polyclonal Hypergammaglobulinemia in Mantle

Makoto Hirokawa Division of Hematology, Departments of Internal Medicine, Akita, Japan

Muneyasu Lee Division of Hematology, Departments of Internal Medicine, Akita, Japan

Atsushi Kitabayashi Division of Hematology, Departments of Internal Medicine, Akita, Japan

Akihiko Chubachi Division of Hematology, Departments of Internal Medicine, Akita, Japan

Toshihiro Itoh Division of Hematology, Departments of Internal Medicine, Akita, Japan

Ikuo Miura Division of Hematology, Departments of Internal Medicine, Akita, Japan

Masahiro Saitoh Pathology, Akita University School of Medicine, Akita, Japan

Akira B. Miura Division of Hematology, Departments of Internal Medicine, Akita, Japan

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Abstract

We investigated the mechanism of polyclonal B cell differentiation in mantle cell lymphoma (MCL) using peripheral blood mononuclear cells (PBMC) from a patient with MCL in leukemic stage presenting polyclonal hypergammaglobulinemia. Patient T cells not only responded to autologous non-T cells but induced polyclonal production of IgG in vitro. Flow cytometric analysis of PBMC showed the increased conversion of CD4+ T cells from the naive to the memory state. We propose the possible mechanism that autoreactive T cells may be involved in polyclonal B cell differentiation in this monoclonal B cell disorder.

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Autoreactive T Cell-Dependent Polyclonal Hypergammaglobulinemia in Mantle

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Autoreactive T Cell-Dependent Polyclonal Hypergammaglobulinemia in Mantle

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