Adhesion Molecule Expression on B-Cells from Acute and Chronic Lymphoid Leukemias

G. De Rossi Hematology, Human Biopathology Department, University “La Sapienza”, Rome, Italy

C. Tenca Department of Human Anatomy, University of Genova, Genova, Italy

G. Cerruti Department of Human Anatomy, University of Genova, Genova, Italy

A. Favre Department of Human Anatomy, University of Genova, Genova, Italy

D. Zarcone Department of Human Anatomy, University of Genova, Genova, Italy

A. Tabilio Hematology and Clinical Immunology, Department of Clinical Medicine, Pathology and Pharmacology, University of Perugia, Genova, Italy

F. R. Mauro Hematology, Human Biopathology Department, University “La Sapienza”, Rome, Italy

L. Annino Hematology, Human Biopathology Department, University “La Sapienza”, Rome, Italy

C. E. Grossit Department of Human Anatomy, University of Genova, Genova, Italy; National Institute for Cancer Research, Genova, Italy

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Abstract

Adhesion molecule expression on acute and chronic lymphoid leukemia cells of B lineage (B-ALL and B-CLL) may subserve several functions. Adhesion of leukemic cells to endothelial cells and to extracellular matrix components is relevant to homing, trafficking and spread of the malignant cells, and thus to clinical presentation, course and disease prognosis. Adhesive interactions between malignant cells and accessory cells, particularly stromal cells in the bone marrow environment, may support growth of the malignant cells via cytokine-delivered messages. They may also deliver signals that prevent or trigger programmed cell death of tumor cells.

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Adhesion Molecule Expression on B-Cells from Acute and Chronic Lymphoid Leukemias

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Adhesion Molecule Expression on B-Cells from Acute and Chronic Lymphoid Leukemias

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