Objective Response of Multiple Myeloma to Cyclosporin A

Peter H. Wiernik Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

Janice P. Dutcher Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

Andrea N. Leaf Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

Zenghua Liao Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

Elisabeth Paietta Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

David L. Rosenstreich Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

Abstract

Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A, one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.

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Objective Response of Multiple Myeloma to Cyclosporin A

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Objective Response of Multiple Myeloma to Cyclosporin A

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