Acute Myeloblasts Leukemia Associated with an Intermediate State Between the Healthy Carrier State and Adult T-cell Leukemia

Yasunori Kawachi Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan

Ayako Watanabe Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan

Yukihiro Sakamoto Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan

Takako Abe Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan

Tatsumi Uchida Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan

Masanori Sacho Department of Pathology, Takamatsu Red Cross Hospital, Kagawa, Japan

Masaharu Mori Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan

Kojun Setsu First Department of Pathology, Okayama University Medical School, Okayama, Japan

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Abstract

This report describes an intermediate state between the human T-cell lymphotropic virus type I (HTLV-I) healthy carrier and adult T-cell Leukemia (ATL) who developed acute myeloblasts leukemia (AML, FAB subtype M2). The polyclonal integration of HTLV-I proviral DNA was demonstrated in the peripheral blood lymphoid cells, whereas AML cells had no HTLV-I proviral DNA. The patient achieved remission after combination chemotherapy but cells with lobulated nuclei persist at a low level and the polyclonal integration of HTLV-I proviral DNA is still demonstrated. We suggest that the patients with the integration of HTLV-I proviral DNA might develop secondary neoplasms more frequently than healthy carriers and this case stresses the need to exercise caution with these patients. The relationship between HTLV-I and AML is briefly discussed.

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Acute Myeloblasts Leukemia Associated with an Intermediate State Between the Healthy Carrier State and Adult T-cell Leukemia

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Acute Myeloblasts Leukemia Associated with an Intermediate State Between the Healthy Carrier State and Adult T-cell Leukemia

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