AML M1 and M2 with Eosinophilia and AML M4Eo: Diagnostic and Clinical Aspects

Abstract

AML with eosinophilia belongs to the morphologic cytogenetic entity M1/M2 t(8;21) with the involvement of the genes AMLI/ETO. These eosinophils differ only slightly from normal eosinophils with one rare exception i.e. Auer rods in eosinophils which has only been found on peroxidase staining: This subtype belongs to the good prognosis group of AML. AML with inv(16) (mostly M4Eo) per se is a morphologic-cytogenetic entity with inv (16),—rarely t(16; 16) and the genes MYL 11/CBF beta involved. The eosinophils show special abnormalities. AML with inv(16) also belongs to the good prognosis group of AML.

Key Words:

• AML
• Eosinophils t(8;21)
• inv(16)