Administration of rhG-CSF Increases Complete Remission Rates After CHOP and ProMACE/CytaBOM for Non-Hodghn's Lymphoma: A Pilot Study

Abstract

To evaluate the clinical effects of the administration of recombinant human granulocyte-stimulating factor (rhG-CSF) post chemotherapy for patients with advanced-staged intermediate-grade or high-grade non-Hodgkin's malignant lymphoma (NHL), we conducted this multicenter study and compared the responses between both the regimens, CHOP as a first-generation chemotherapy and ProMACE/CytaBOM as a third-generation chemotherapy, when combined with the rhG-CSF administration. In this multicenter study, where forty patients were registered, patients in both the CHOP and ProMACE/CytaBOM groups were treated with the original regimen designs without the necessity of reducing drug dosages when combined with the administration of rhG-CSF. The administration of rhG-CSF post both of the cytotoxic therapies brought about much higher rates of complete remission in both the groups (CHOP, 75 percent; ProMACE/CytaBOM, 75 percent), as compared with those of the previous study without the rhG-CSF administration. Regarding response rates according to the International prognostic factor index, the CHOP group showed a lower rate of complete remission in patients with risk factors, compared with ProMACE/CytaBOIM group. This result suggested that the administration of rhG-CSF may offer one important approalch for improving the first-line therapy for aggressive NHL with high risk factors.

Key Words:

• non-Hodgkin's lymphoma
• rhG-CSF
• dose intensity
• CHOP
• ProMACE/CytaBOM