Marked Bone Marrow Eosinophilia at the Time of Relapse of Acute Myeloblastic Leukaemia in Association with the Appearance of Translocation t(12;20)(q24;q ll)

F. Partridge Haematology Department, George Eliot Hospital, Nuneaton, England

W. Richardson Haematology Department, George Eliot Hospital, Nuneaton, England

P. Kearns Haematology Department, George Eliot Hospital, Nuneaton, England

R. Wilcox Haematology Department, George Eliot Hospital, Nuneaton, England

G. Majumdar Haematology Department, George Eliot Hospital, Nuneaton, England

Abstract

We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clonet(8;21)(q22;q22), t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.

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Marked Bone Marrow Eosinophilia at the Time of Relapse of Acute Myeloblastic Leukaemia in Association with the Appearance of Translocation t(12;20)(q24;q ll)

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Marked Bone Marrow Eosinophilia at the Time of Relapse of Acute Myeloblastic Leukaemia in Association with the Appearance of Translocation t(12;20)(q24;q ll)

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