Acute Tumor Lysis Syndrome Following Intrathecal Methotrexate

Mustafa Benekli Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

Ibrahim H. Gullu Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

M. Cemil Savas Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

Abdurrahman Kadayifgi Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

M. Kadri Altundag Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

Gulten Tekuzman Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

Dinner Firat Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

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Abstract

We report a 17-year-old boy with meningeal involvement of lymphoblastic lymphoma who experienced acute tumor lysis syndrome following intrathecal administration of methotrexate. Intrathecally injected methotrexate provides a slow- release reservoir of methotrexate into the bloodstream with prolonged cy totoxic levels. To the best of our knowledge, this is the second case of tumor lysis syndrome to be described after intrathecal methotrexate injection. The pathogenesis of this unusual complication of intrathecal chemotherapy is discussed.

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Acute Tumor Lysis Syndrome Following Intrathecal Methotrexate

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Acute Tumor Lysis Syndrome Following Intrathecal Methotrexate

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