Primary Adrenal Lymphoma Associated with Adrenal Insufficiency: A Distinct Clinical Entity

Mark Pimentel Departments of Medicine and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada

James B. Johnston Departments of Medicine and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada

Donald R. Allan Departments of Medicine and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada

Howard Greenberg Departments of Medicine and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada

Charles N. Bernstein Departments of Medicine and Radiology, University of Manitoba, Winnipeg, Manitoba, CanadaCorrespondence[email protected]

Abstract

We describe a case of a 42 year old male who presented with Addison's disease resulting from primary lymphoma of the adrenals. Our case and a review of the literature indicates that this distinct entity has some unique clinical and radiologic features. In this entity, the lymphoma tends to be extranodal and have a poor prognosis. In addition, the computed tomography (CT) images have the unique appearance of enlargement of the adrenal gland with maintenance of the adreniform shape. We suggest that primary adrenal lymphoma is a distinct clinical entity and should be considered in patients with an elevated serum lactate dehydrogenase, characteristic CT findings and Addison's disease.

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Primary Adrenal Lymphoma Associated with Adrenal Insufficiency: A Distinct Clinical Entity

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Primary Adrenal Lymphoma Associated with Adrenal Insufficiency: A Distinct Clinical Entity

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