HMGI-C, a Member of the High Mobility Group Family of Proteins, is Expressed in Hematopoietic Stem Cells and in Leukemic Cells

Birgit Rommel Center of Human Genetics and Genetic Counseling, University of Bremen, Bremen

Piere Rogalla Center of Human Genetics and Genetic Counseling, University of Bremen, Bremen

Andrea Jox Dept. of Internal Medicine I, University Hospital, Cologne

Christoph V. Kalle Dept. of Internal Medicine, University Hospital, Freiburg, Germany

Bernd Kazmierczak Center of Human Genetics and Genetic Counseling, University of Bremen, Bremen

Jürgen Wolf Dept. of Internal Medicine I, University Hospital, Cologne

Jörn Bullerdiek Center of Human Genetics and Genetic Counseling, University of Bremen, Bremen

show all

Abstract

The human HMGI-C gene encoding a member of the high mobility group protein family normally is expressed only during embryonic/fetal development hut in none of the adult tissues tested so far. Recently, the HMGI-C gene has attracted a lot of interest since its rearrangements seem to underlie the development of frequent benign mesenchymal tumors. We have therefore checked CD34 positive hematopoietic stem cells and their normal and malignant descendants for HMGI-C expression. CD34 positive stem cells from healthy donors and the leukemia samples tested were positive while all peripheral blood samples from healthy volunteers were negative. We have concluded that the expression of the HMGI-C gene in leukemia seems to be a secondary effect due to abnormal stem cell proliferation and might be a sensitive tumor marker for particular types of leukemia.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

HMGI-C, a Member of the High Mobility Group Family of Proteins, is Expressed in Hematopoietic Stem Cells and in Leukemic Cells

Information for

Open access

Opportunities

Help and information

HMGI-C, a Member of the High Mobility Group Family of Proteins, is Expressed in Hematopoietic Stem Cells and in Leukemic Cells

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature