Castleman's Disease in a 44-year-old Male with Neurofibromatosis and Pheochromocytoma

H. Tom Stelfox Departments of Medicine and Pathology, The Toronto Hospital, Toronto, Ontario, Canada

A. Keith Stewart Departments of Medicine and Pathology, The Toronto Hospital, Toronto, Ontario, Canada

Dennis Bailey Departments of Medicine and Pathology, The Toronto Hospital, Toronto, Ontario, Canada

David Harrison Departments of Medicine and Pathology, The Toronto Hospital, Toronto, Ontario, Canada; Division of Cardiology, The Toronto Hospital, Eaton Wing 11-219,200 Elizabeth Street, Toronto, Ontario, Canada, M5G 2C4

Abstract

A case of Castleman's disease in a patient with type I neurofibromatosis and pheochromocytoma is reported. The association of pheochromocytoma and neurofibromatosis is well documented, but uncommon. Castleman's disease has not been previously documented in a patient with neurofibromatosis or pheochromocytoma and may represent a previously unrecognized association of this disease. Castleman's disease is an interleukin-6 (IL-6) mediated B-cell proliferation. We postulate a relationship between pheochromocytoma IL-6 secretion and Castleman's disease. The relevant literature relating to this unusual case is reviewed.

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Castleman's Disease in a 44-year-old Male with Neurofibromatosis and Pheochromocytoma

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Castleman's Disease in a 44-year-old Male with Neurofibromatosis and Pheochromocytoma

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